Pharmaceutical name 英文藥名﹕Radix Gentianae longdancao
Biological name 學名﹕Gentiana scabra Bge/ Gentiana triflora Pall., 三 花 龍 膽/ Gentiana manshurica Kitag/ Gentiana regescens Fransh/ Gentiana arisanensis Hayata 阿里山龍膽
Other Names 別名﹕long dan 龍膽/ long cao 膽草/ ku dan 苦膽/ ling you 陵游/ guan yin cao 觀音草
Common Name 常用英文名﹕gentiana
Distribution 分佈﹕
throughout China: Northeastern provinces (Manchuria), Anhui, Jingjiang of Jiangsu,Shandong. Those produced in Huzhou of Zhejiang is deemed best.
全中國﹐ 尤其在東北﹐ 安徽﹐ 江蘇﹐ 山東。 浙江湖州產 的一般認為品質較佳。
Properties (characteristics) 性味:bitter, cold, non toxic 苦寒無毒
Channels (meridians) entered 歸經﹕gallbladder, liver, stomach/ 肝 ﹐膽﹐膀胱
Actions & Indications 用途﹕
expels damp heat from liver and gallbladder channels with symptoms of high fever and seizures, red swollen sore throat and eyes, swollen and painful ears or sudden loss of hearing, boils in mouth and tongue, hepatitis with jaundice, vaginal discharge, damp and itchy groln area, cystitis, inflammation of the urethra, boils on skin, feverish malaria, chronic gastritis, eczema, conjunctivitis, hypertension with dizziness and tinnitus, malaria, and herpes zoster.
高熱驚厥,目赤咽痛,口舌生瘡, 濕熱黃疸,帶下,陰部濕癢,膀胱炎,尿道炎,疥瘡,瘧疾發熱,慢 性胃黏膜炎,皮膚濕疹﹐血壓高兼頭暈耳鳴﹐帶狀庖疹。
Medical Function 藥理﹕
1. Decoction of long dan cao inhibits Pseudomonas aeruginosa﹐ Proteus species, Salmonella typhi and Staphylococcus aureaus, certian skin fungi and Leptospirosis.
2. Anti-inflammation.
3. sedative effect
4. muscle relaxing effect
5. Small amount taken half hour before meals can stimulate the digestive system and promotes bile, hydrochloride acid and other digestive enzymes secretion; thus promotes appetite. If taken after meals causes the secretion of digestive juices to go down. If large amount is taken, it interferes with digestion, sometimes creates headache and dizziness.
6. lowers ALT, choleretic effect; and protects liver from damage
7. anti-oxidant effect [1]
8. anti-tuberculosis [2]
9. inhibits production of melanin
1. 龍膽煎劑對綠膿桿菌 (Pseudomonas aeruginosa) ﹐變形桿菌(Proteus species) ﹐傷寒桿菌 (Salmonella typhi)﹐金黃 色葡萄 球菌(Staphylococcus aureaus) ﹐某些皮膚真菌及鈎端 螺絲體 (Leptospirosis) 等 ,均有 一定的抑制作用;
2. 抗炎作用﹔
3. 鎮靜作用﹔
4. 使肌肉鬆弛作用﹔
5. 龍膽草少量飯前口服 ,可反 射性增強胃液分泌,並能增加游離酸,有助消化,增進食慾。如飯後服食則會使消化液體分泌下降。大劑量影響消化有時可致頭暈﹐頭痛。
6. 保肝降低谷丙轉氨脢 ﹐ 與保護肝臟﹐利膽作用。
7. 抗氧化作用
8. 抗肺結核病作用
9. 阻擋角質細胞傳遞產生黑色素訊息到黑色素母細胞,阻斷黑色素的生成。
Chemical ingredients 化學成份﹕
gentiopicrin C16H25O 1/2 H20/ 龍胆苦甙
gentianose C18H32O16/ 龍膽三醣
swertiamarin/ 獐牙菜苦甙
gentisin/ 龍胆酮
gentiobiose/ 龍膽二糖
gentisic acid/ 龍胆酸
Dosage 用量﹕
03 to 3 g per day as decoction or powder form
一日量﹕0.3 ~ 3 克﹐水煎或作粉劑。
Samples of formulae 複方樣本:
to strengthen digestive system--
1. long dan cao 2 g, da huang 1 g, huang bai 1 g, water 400 c.c. Simmer till 150 c.c. Make into 3 serving per day. (source: He Han Yao Ying Yong Fang)
2. long dan cao powder 0.5 g, huang bai powder 0.5 g, sheng jiang powder 0.3 g, hui xiang powder 0.3 g, ji nei jin powder 0.5 g, burnt shan zha powder 1 g, gui zhi powder 0.3 g, mix together. Make into 3 servings per day.
治胃弱--
1. 龍膽草2克 , 大黃 1克 ,黃 柏 1 克﹐ 水400公 撮,煎至150公 撮,一日三回分服。
2. 龍膽草末0.5克 ,黃 柏末0.5克 ,生薑末0.3克 , 桂 枝 末0.3克 ,茴香末0.3克 ,雞內金末0.5克 ,山查炭末1克 ,以上混和,一日三回分服。(和漢藥應用方)
Cautions 禁忌﹕
not to use in case of diarrhea due to pixu (spleen deficient) . Be careful not to use gui jiu by mistake. Gui jiu is a poisonous herb for cancer treatment.
脾虛﹐便溏及非實火症忌用.
注 意﹕龍膽草與鬼臼的形狀相似。鬼臼是用 來治癌症。有毒。
Notes:
[1] Biochim Biophys Acta. 1998 Jan 15;1389(2):81-90. Isoorientin-6"-O-glucoside, a water-soluble antioxidant isolated from Gentiana arisanensis.Ko FN, Chu CC, Lin CN, Chang CC, Teng CM.
Pharmacological Institute, College of Medicine, National Taiwan University, Taipei.
[2] Zhong Yao Tong Bao. 1985 Dec;10(12):33-4.
[Antituberculous constituents of Gentiana rhodantha]
[Article in Chinese], Liu YW.
(by Joe Hing Kwok Chu)
Medical Records: JUN 2000 suffered from obstructive hydrocephalus (Taichung Veterans General Hospital)/ 4 SEP 2003 Taichung Veterans General Hospital confirmed suspect subarachnoid cyst 34×12mm(inference 30×10×10mm at 28 AUG)/ 29 SEP 2003 Chang Gung Memorial Hospital Linkou Branch surgery to remove the brain tumor, diameter of 47.5mm/ FEB 2007 benign neoplasm of brain/ DEC 2010 China Medical University Hospital Cancer Center for the Chinese medical treatment.
Status
Current conditions ICD-9-CM:
2003
225.0 BENIGN NEOPLASM OF BRAIN
345.90 UNSPECIFIED EPILEPSY WITHOUT MENTION OF INTRACTABLE EPILEPSY
2010
225.0 BENIGN NEOPLASM OF BRAIN
345.90 UNSPECIFIED EPILEPSY WITHOUT MENTION OF INTRACTABLE EPILEPSY
2012
225.0 BENIGN NEOPLASM OF BRAIN
345.90 UNSPECIFIED EPILEPSY WITHOUT MENTION OF INTRACTABLE EPILEPSY
375.15 TEAR FILM INSUFFICIENCY,UNSPECIFIED
367.89 OTHER DISORDERS OF REFRACTION AND ACCOMMODATION
377.61 ASSOCIATED WITH NEOPLASMS
729.1 MYALGIA AND MYOSITIS, UNSPECIFIED
719.39 PALINDROMIC RHEUMATISM,MULTIPLE SITES
680.0 CARBUNCLE AND FURUNCLE, FACE
378.41 ESOPHORIA
311 DEPRESSIVE DISORDER, NOT ELSEWHERE CLASSIFIED
523.8 OTHER PERIODONTAL DISEASES(PERIODONTAL POCKET,GINGIVAL POLYP)
681.02 ONYCHIA AND PARONYCHIA OF FINGER
2013
225.0 BENIGN NEOPLASM OF BRAIN
345.90 UNSPECIFIED EPILEPSY WITHOUT MENTION OF INTRACTABLE EPILEPSY
704.8 OTHER DISEASES OF HAIR AND HAIR FOLLICLES
706.1 OTHER ACNE
444.22 ARTERIAL EMBOLISM AND THROMBOSIS OF LOWER EXTREMITY
375.15 TEAR FILM INSUFFICIENCY,UNSPECIFIED
367.89 OTHER DISORDERS OF REFRACTION AND ACCOMMODATION
377.61 ASSOCIATED WITH NEOPLASMS
378.41 ESOPHORIA
728.85 (728.850) SPASM OF MUSCLE
353.4 LUMBOSACRAL ROOT LESIONS,NOT ELSEWHERE CLASSIFIED
780.52 (780.520) OTHER INSOMNIA
788.43 NOCTURIA
2014
225.0 BENIGN NEOPLASM OF BRAIN
345.90 UNSPECIFIED EPILEPSY WITHOUT MENTION OF INTRACTABLE EPILEPSY
374.05 TRICHIASIS WITHOUT ENTROPION
372.72 CONJUNCTIVAL HEMORRHAGE
375.15 TEAR FILM INSUFFICIENCY,UNSPECIFIED
367.89 OTHER DISORDERS OF REFRACTION AND ACCOMMODATION
377.61 ASSOCIATED WITH NEOPLASMS
378.41 ESOPHORIA
2015
225.0 BENIGN NEOPLASM OF BRAIN
345.90 UNSPECIFIED EPILEPSY WITHOUT MENTION OF INTRACTABLE EPILEPSY
705.83 HIDRADENITIS
698.8 OTHER PRURITIC CONDITIONS
686.9 UNSPECIFIED LOCAL INFECTIONS OF SKIN AND SUBCUTANEOUS TISSUE
686.09 OTHER PYODERMA
272.0 PURE HYPERCHOLESTEROLAEMIA (FAMILIAL HYPERCHOLESTESTEROLEMIA)
729.1 MYALGIA AND MYOSITIS, UNSPECIFIED
719.39 PALINDROMIC RHEUMATISM,MULTIPLE SITES
377.61 ASSOCIATED WITH NEOPLASMS
311 DEPRESSIVE DISORDER, NOT ELSEWHERE CLASSIFIED
307.48 REPETITIVE INTRUSIONS OF SLEEP
705.81 DYSHIDROSIS
372.72 CONJUNCTIVAL HEMORRHAGE
680.2 CARBUNCLE AND FURUNCLE, TRUNK
523.3 ACUTE PERIODONTITIS(ACUTE PERICORONITIS)
Current conditions ICD-10-CM:
2016
E780 Pure hypercholesterolemia
G40.909 Epilepsy, unspecified, not intractable, without status epilepticus
L301 Dyshidrosis [pompholyx]
F32.9 Major depressive disorder, single episode, unspecified
D33.2 Benign neoplasm of brain, unspecified
H04.123 Dry eye syndrome of bilateral lacrimal glands
H47.529 Disorders of visual pathways in (due to) neoplasm, unspecified side
H02.052 Trichiasis without entropian right lower eyelid
H11.31 Conjunctival hemorrhage, right eye
H52.6 Other disorders of refraction
H50.51 Esophoria
H02.055 Trichiasis without entropian left lower eyelid
H47.099 Other disorders of optic nerve, not elsewhere classified, unspecified eye
F51.8 Other sleep disorders not due to a substance or known physiological condition
G40.901 Epilepsy, unspecified, not intractable, with status epilepticus
L0881 Pyoderma vegetans
B009 Herpesviral infection, unspecified
J069 Acute upper respiratory infection, unspecified
M79.1 Myalgia
M12.39 Palindromic rheumatism, multiple sites
2016
E780 Pure hypercholesterolemia
G40.909 Epilepsy, unspecified, not intractable, without status epilepticus
L301 Dyshidrosis [pompholyx]
F32.9 Major depressive disorder, single episode, unspecified
D33.2 Benign neoplasm of brain, unspecified
H04.123 Dry eye syndrome of bilateral lacrimal glands
H47.529 Disorders of visual pathways in (due to) neoplasm, unspecified side
H02.052 Trichiasis without entropian right lower eyelid
H11.31 Conjunctival hemorrhage, right eye
H52.6 Other disorders of refraction
H50.51 Esophoria
H02.055 Trichiasis without entropian left lower eyelid
H47.099 Other disorders of optic nerve, not elsewhere classified, unspecified eye
F51.8 Other sleep disorders not due to a substance or known physiological condition
G40.901 Epilepsy, unspecified, not intractable, with status epilepticus
L0881 Pyoderma vegetans
B009 Herpesviral infection, unspecified
J069 Acute upper respiratory infection, unspecified
M79.1 Myalgia
M12.39 Palindromic rheumatism, multiple sites
Current treatment centers:
GP/ The department of Neurosurgical emergency & Critical Care of Chang Gung Memorial Hospital Linkou Branch/ TCM oncology of China Medical University Hospital Cancer Center/ and Taichung Hospital, Ministry of Health and Welfare
Contents of reference sources:
MIMS- Search drug information/ interaction/ images & medical diagnosis.
Complementary and Alternative Healing University- Dictionary of Chinese Herbs. http://alternativehealing.org
Database 醫砭‧沈藥子 http://yibian.hopto.org
Traditional Chinese Medicine (TCM) Wiki http://www.tcmwiki.com/
Thursday, December 4, 2014
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