wu zhu yu 吳茱萸

Pharmaceutical name英文藥名：
Fructus Evodiae Rutaecarpae
Latin botanical name拉丁學名：
Evodia rutaecarpa (Juss.) Benth.,
Evodia rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang,
Common Name英文名：
evodia fruit
Other Names別名：
wu yu 吳萸，qu yao zi 曲藥子，fu la zi 伏辣子，cha la 茶辣，chou pao zi 臭泡子。
Distribution分佈：
Guizhou, Sichuan, Guangxi, Hunan, Yunnan, Shaanxi, Zhejiang
贵州， 四川，廣西，湖南，云南， 陝西， 浙江。
Properties (characteristics)性味：
acrid, bitter, hot, mildly toxic.
辛，苦，熱，有小毒。
Channels (meridians) entered歸經：
kidney, liver, spleen, stomach
腎，肝，脾，胃。
Actions & Indications主治：
warms the middle, lower qi, rids of cold of stomach, lower blood pressure, for vomiting, excess acid of stomach, pain in solar plexus, cold type of hernia, cold and dampness of swelling of legs. Lead fire downward.
溫 中 下 氣 ， 止 痛 除 濕 ， 善 於 溫 散 肝 胃 之 寒 ， 降 血 壓。
嘔 吐 吞 酸 ， 胃 脘 痛 ， 腹 內 絞 痛 ， 泄 瀉 ， 寒 疝 痛 ， 寒 濕 腳 氣 。
Medical Function药理：
Relaxes blood vessels by promoting the excitement of the inner skin of blood vessels, clearing the pathway of calcium ion, and releasing nitrogen oxide.
促進血管內皮興奮，打通鈣離子的通道，釋放出一氧化氮，以致放鬆血管。
抑制血小板聚集。抑制血小板血栓及纖維蛋白血栓形成。
鎮痛，升高體溫作用，大量時能興奮中樞，並引起視力障礙﹐錯覺。
Chemical ingredients化學成份：
1.limonin 檸檬內酯 [1];rutaevine 吳茱萸苦素[2]; evodol吳茱萸內酯醇[3]; obacunone 黃柏酮[4]; rutaevine acetate 吳茱萸苦素乙酯[5]; 12 alpha-hydroxylimonin 12 a-羥基檸檬內酯; 12 alpha-hydroxyevodol 12 a-羥基吳茱萸內酯醇[6]; 6alpha-acetoxy-5-epilimonin; 6alpha-acetoxy-5-epilimonin[6,7]; Jangomolide[8]; GraucinA[9].
2. (1).evocarpine 吳茱萸卡品鹼[10]; dihydroevocarpine; 1-methyl-2-undecyl-4 (1H)-quinolone; 1-methyl-2-pentadecenyl-4(1H)-quinolone[11]; 1-methyl-2-[(Z) -6 -undecenyl]-4 (1H)-quinolone; 1-methyl-2-[Z) -6-pentadecenyl]-4 (1H) -quinolone;1-methyl-2-[(Z)-10-pentadeceny;]-4 (1H)-quinolone; 1-methyl-2-(6Z, 9Z)-6, 9-pentadecadienyl) -4 (1H) -quinolone; 1-methyl-2-([4Z, 7Z]) -4, 7-tridecxadienyl) -4 (1H)-quinolone[6].
(2). evodiamine; rutaecarpine; wuchuyine; hydroxyevodiamine 羥基吳茱萸鹼; dihydrorutaecarpine; 14-formyldihydrorutaecarpine[12];Goshuyuamide-I, Goshuyuamide-II[13]; evodiamide[14].
(3).N, N-diumethyl-5-methoxy tryptamine; N-methylanthranylamide; disynephrine[15]; cGMP[16].
3. arachidoside; isopentenyl-flavone[17].
4. evoden; alpha-ocimene; cis-beta-ocimene.
5. evodinone; evogin[18].
Dosage用量：
3 to 9 g. Use with gan cao to reduce side effects.
3～9克。加甘草可以减輕其副作用。
Samples of formulae:
For headaches caused by vasomoter dysfunction:
Name of formula: wu zhu yu tang
Composition: wu zhu yu, ren shen, da zao, shen jiang.
吳茱萸湯﹕由吳茱萸﹐人參﹐大棗﹐生姜四味所組成，所治的厥陰頭痛，即血管神經性 頭痛。
Modern Research现代研究：
"Antidementic Drug Discovery from Oriental Herb Medicine: Dehydroevodiamine.HCl (DHED) extracted from Evodia Rutaecarpa Bentham prevents Impairment of Learning and Memory and Neuronal loss" - Cheol Hyoung Park (Korea).
Feeding the decoction to dogs, showed that it lowered the blood pressure but when combined with gan cao, the effect disappeared. The lowering of blood pressure is the result of the expansion of the peripheral blood vessels and it is caused by secretion of histamine. The decoction showed that it affect the activities of the small intestine of rabbits. Higher concentration of decoction inhibited the activities and lower concentration of it enhanced the activities.
用其煎劑給狗灌胃，有明顯的降壓作用，但與甘草配伍，其降壓作用消失。其壓降作用主要是擴張外周血管所致，且與組織胺釋放有關。其煎劑對家兔小腸活動的影響。低濃度時興奮，高濃度時抑制。
Cautions禁忌：
not suitable for shi zheng (strong pattern) , yinxu (yin deficient) and high fire body type.
不適用於實證, 陰虛火旺之體質。


陰虛火旺症状： 陰莖強硬不倒，精液自流，頭暈神疲，失眠多夢，腰膝酸軟，五心煩熱，口乾盜汗，舌紅少苔，脈細數。